The Chesapeake Society of Gastroenterology Nurses and Associates
The Chesapeake Society of Gastroenterology Nurses and Associates is affiliated with the National Society of Gastroenterology Nurses and Associates (SGNA). CSGNA is a group of professional nurses and associates of various backgrounds whose goal is to provide optimal care to patients seeking treatment for gastrointestinal disorders. Gastrointestinal (GI) Nurses and Associates practice in hospitals, ambulatory endoscopy centers, and physician offices. We strive to enhance our own clinical knowledge through educational programs incorporating new concepts in an ever-changing technology.
The CSGNA is looking for enthusiastic members in making our Society the best that it can be.
Latest GI News
- Zenker’s Diverticulum Per-Oral Endoscopic Myotomy Techniques: Changing ParadigmsZenker’s diverticulum (ZD) can be treated by open surgery, rigid endoscopy, or flexible endoscopy.1 Standard endoscopic septotomy is highly successful with symptom recurrence on 11%–30% of cases. ZD can be treated with per-oral endoscopic myotomy (Z-POEM) with data showing a feasibility of 87.5% and clinical improvement of 100%.2 Potential advantages over standard endoscopic septotomy is complete septum division, decreasing the risk of symptom recurrence. The aim of this video is ... read more
- Unexpected Cause of Abdominal Pain and Genitourinary Symptoms
- Vedolizumab Does Not Impair Sperm DNA Integrity in Men With Inflammatory Bowel DiseaseVedolizumab, an α4ß7 integrin IgG1 monoclonal antibody, has a favorable safety profile.1 However, data concerning the effect of vedolizumab exposure on male reproduction are limited.2 No study has investigated the impact of vedolizumab on semen quality, which is the standard surrogate marker of male fertility. The basic evaluation of sperm concentration, morphology, and motility does not evaluate the genomic integrity of the spermatozoa. Because intact DNA integrity is essential for ... read more
- Penetration of the Esophageal Epithelium by Dust Mite Antigen in Patients With Eosinophilic Esophagitis
- Association Between Antibiotics in the First Year of Life and Celiac DiseaseThe intestinal microbiota is believed to be involved in the pathogenesis of celiac disease, in addition to genetic variants and dietary gluten. The gut microbiota is strongly influenced by systemic antibiotics—especially in early life. We explored the association between exposure to a systemic antibiotic in the first year of life and risk of diagnosed celiac disease. ... read more
- HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic ResponseChronic hepatitis C virus (HCV) infection is an important risk factor for hepatocellular carcinoma (HCC). Despite effective antiviral therapies, the risk for HCC is decreased but not eliminated after a sustained virologic response (SVR) to direct-acting antiviral (DAA) agents, and the risk is higher in patients with advanced fibrosis. We investigated HCV-induced epigenetic alterations that might affect risk for HCC after DAA treatment in patients and mice with humanized livers. ... read more
- GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2Interleukin 6 (IL6) and tumor necrosis factor contribute to the development of colitis-associated cancer (CAC). We investigated these signaling pathways and the involvement of G protein subunit alpha i1 (GNAI1), GNAI2, and GNAI3 in the development of CAC in mice and humans. ... read more
- Real-Time Targeted Genome Profile Analysis of Pancreatic Ductal Adenocarcinomas Identifies Genetic Alterations That Might Be Targeted With Existing Drugs or Used as BiomarkersIt has been a challenge to select treatment for patients with pancreatic ductal adenocarcinomas (PDACs) based on genome alterations. We performed targeted genomic profile analyses of a large number of PDACs to assess the full spectrum of actionable genomic alterations. ... read more
- Not your typical inflammatory bowel disease flare: diarrhea and weight loss masquerading as recrudescence of ulcerative colitis
- Gastric Parietal Cell Physiology and Helicobacter pylori–Induced DiseaseAcidification of the gastric lumen poses a barrier to transit of potentially pathogenic bacteria and enables activation of pepsin to complement nutrient proteolysis initiated by salivary proteases. Histamine-induced activation of the PKA signaling pathway in gastric corpus parietal cells causes insertion of proton pumps into their apical plasma membranes. Parietal cell secretion and homeostasis are regulated by signaling pathways that control cytoskeletal changes required for apical membrane remodeling and organelle ... read more