If you are a member of SGNA and have selected Chesapeake SGNA as your region, you should been emailed a ballot. The vote is on the Chesapeake SGNA and Delaware SGNA merging into a new SGNA Region. Only those from the list SGNA membership site for Chesapeake Region be allowed to vote. Please do not forget to write your SGNA number on your ballot. Please check your junk email. Contact: [email protected] for misplaced ballot.
The Chesapeake Society of Gastroenterology Nurses and Associates
The Chesapeake Society of Gastroenterology Nurses and Associates is affiliated with the National Society of Gastroenterology Nurses and Associates (SGNA). CSGNA is a group of professional nurses and associates of various backgrounds whose goal is to provide optimal care to patients seeking treatment for gastrointestinal disorders. Gastrointestinal (GI) Nurses and Associates practice in hospitals, ambulatory endoscopy centers, and physician offices. We strive to enhance our own clinical knowledge through educational programs incorporating new concepts in an ever-changing technology.
The CSGNA is looking for enthusiastic members in making our Society the best that it can be.
Latest GI News
- Amino Acid Substitutions in Genotype 3a Hepatitis C Virus Polymerase Protein Affect Responses to SofosbuvirSofosbuvir is a frequently used pan-genotype inhibitor of hepatitis C virus (HCV) polymerase. This drug eliminates most chronic HCV infections and resistance-associated substitutions in the polymerase are rare. However, HCV genotype 3 responds slightly less well to sofosbuvir-based therapies than other genotypes. We collected data from England’s National Health Service Early Access Program to search for virus factors associated with sofosbuvir treatment failure. ... read more
- Endoscopic Surveillance of Barrett’s Esophagus Using Volumetric Laser Endomicroscopy with Artificial Intelligence Image EnhancementBarrett’s esophagus (BE) is a change from normal esophageal squamous epithelium to specialized intestinal metaplasia. BE is the major risk factor for esophageal adenocarcinoma, the incidence of which continues to increase.1 Interventions to impact the increasing incidence of esophageal adenocarcinoma are limited owing to 2 factors: (1) many patients with BE may remain undiagnosed until a symptomatic cancer arises2 and (2) traditional surveillance approaches are imperfect at identifying which BE ... read more
- Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to HypoxiaMost pancreatic ductal adenocarcinomas (PDACs) express an activated form of KRAS, become hypoxic and dysplastic, and are refractory to chemo- and radiation-therapies. To survive in the hypoxic environment, PDAC cells upregulate enzymes and transporters involved in pH regulation, including the extracellular facing carbonic anhydrase 9 (CA9). We evaluated the effect of blocking CA9, in combination with administration of gemcitabine, in mouse models of pancreatic cancer. ... read more
- PeriLeve: An Implantable Peritoneovesicular Biopowered Shunt to Manage Patients with Refractory AscitesRefractory ascites affects 5%–10% of all patients with liver cirrhosis and can cause significant abdominal discomfort, difficulty breathing and in extreme cases, chronic abdominal compartment syndrome.1,2 This condition is commonly managed by draining 5–10 L of fluid via large volume paracentesis every 1–2 weeks and patients often experience deteriorating symptoms in the interim as the fluid reaccumulates. The estimated annual cost of managing this condition alone can top $1 billion, ... read more
- Extrinsic Primary Afferent Neurons Link Visceral Pain to Colon Motility Through a Spinal Reflex in MiceProper colon function requires signals from extrinsic primary afferent neurons (ExPANs) located in spinal ganglia. Most ExPANs express the vanilloid receptor TRPV1, and a dense plexus of TRPV1-positive fibers is found around myenteric neurons. Capsaicin, a TRPV1 agonist, can initiate activity in myenteric neurons and produce muscle contraction. ExPANs might therefore form motility-regulating synapses onto myenteric neurons. ExPANs mediate visceral pain, and myenteric neurons mediate colon motility, so we investigated ... read more
- Effects of Serotonin and Slow-Release 5-Hydroxytryptophan on Gastrointestinal Motility in a Mouse Model of DepressionMood disorders and constipation are often comorbid, yet their shared etiologies have rarely been explored. The neurotransmitter serotonin (5-HT) regulates central nervous system and enteric nervous system (ENS) development and long-term functions, including gastrointestinal (GI) motility and mood. Therefore, defects in neuron production of 5-HT might result in brain and intestinal dysfunction. Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in 5-HT biosynthesis. A variant of TPH2 that encodes the ... read more
- Hemoperitoneum: From what, where, and why?... read more
- Analysis of Liver Cancer Cell Lines Identifies Agents With Likely Efficacy Against Hepatocellular Carcinoma and Markers of ResponseHepatocellular carcinomas (HCCs) are heterogeneous aggressive tumors with low rates of response to treatment at advanced stages. We screened a large panel of liver cancer cell lines (LCCLs) to identify agents that might be effective against HCC and markers of therapeutic response. ... read more
- Pantoprazole to Prevent Gastroduodenal Events in Patients Receiving Rivaroxaban and/or Aspirin in a Randomized, Double-Blind, Placebo-Controlled TrialAntiplatelets and anticoagulants are associated with increased upper gastrointestinal bleeding. We evaluated whether proton pump inhibitor therapy could reduce this risk. ... read more
- Endoplasmic Reticulum Stress-Induced Upregulation of STARD1 Promotes Acetaminophen-Induced Acute Liver FailureAcetaminophen (APAP) overdose is a major cause of acute liver failure (ALF). Mitochondrial SH3BP5 (also called SAB) and phosphorylation of c-Jun N-terminal kinase (JNK) mediate the hepatotoxic effects of APAP. We investigated the involvement of steroidogenic acute regulatory protein (STARD1), a mitochondrial cholesterol transporter, in this process and sensitization by valproic acid (VPA), which depletes glutathione and stimulates steroidogenesis. ... read more